This idiom or expression means:

New opportunity.
Starting again something (which was failing) with new energy.

Getting a low interest-rate loan for my restaurant would give my business a new lease on life.

This idiom or expression like question could have any of the following meanings:

What’s your life story?
What are you all about?
What’s your explanation?
What do you want to tell me?
What’s your side of the story?

This idiom or expression means:

You have to face life.
You can’t hide the truth.
You can’t run away from life.
You brought this upon yourself, now you have to face the consequence.

They have everything you could possibly think of.